| First Author | Patterson HC | Year | 2011 |
| Journal | J Immunol | Volume | 187 |
| Issue | 6 | Pages | 2853-8 |
| PubMed ID | 21841126 | Mgi Jnum | J:179254 |
| Mgi Id | MGI:5301508 | Doi | 10.4049/jimmunol.1101143 |
| Citation | Patterson HC, et al. (2011) Cytoplasmic Ig alpha serine/threonines fine-tune Ig alpha tyrosine phosphorylation and limit bone marrow plasma cell formation. J Immunol 187(6):2853-8 |
| abstractText | Igalpha serine 191 and 197 and threonine 203, which are located in proximity of the Igalpha ITAM, dampen Igalpha ITAM tyrosine phosphorylation. In this study, we show that mice with targeted mutations of Igalpha S191, 197, and T203 displayed elevated serum IgG2c and IgG2b concentrations and had elevated numbers of IgG2c- and IgG2b-secreting cells in the bone marrow. BCR-induced Igalpha tyrosine phosphorylation was slightly increased in splenic B cells. Our results suggest that Igalpha serine/threonines limit formation of IgG2c- and IgG2b-secreting bone marrow plasma cells, possibly by fine-tuning Igalpha tyrosine-mediated BCR signaling. |
