| First Author | Rieg T | Year | 2007 |
| Journal | Eur J Pharmacol | Volume | 555 |
| Issue | 2-3 | Pages | 174-7 |
| PubMed ID | 17126319 | Mgi Jnum | J:136788 |
| Mgi Id | MGI:3796971 | Doi | 10.1016/j.ejphar.2006.10.039 |
| Citation | Rieg T, et al. (2007) Adenosine A1 receptors determine effects of caffeine on total fluid intake but not caffeine appetite. Eur J Pharmacol 555(2-3):174-7 |
| abstractText | Adenosine A1 receptor wild-type (+/+) and knockout (-/-) mice were used to elucidate the role of adenosine A1 receptors in caffeine self-administration in a two-bottle choice test and in the effect of caffeine on total fluid intake and plasma renin concentration. With access to water only, adenosine A1 receptor -/- mice showed greater basal fluid intake and greater plasma renin concentration than +/+ mice. Free access to both water and a caffeinated solution (30 mg/100 ml) for 14 days increased total fluid intake only in adenosine A1 receptor +/+ mice (by 23+/-3%), and both total fluid intake and plasma renin concentration were no longer different between genotypes. Mean intake of water and caffeinated solution was not different between adenosine A1 receptor +/+ and -/- mice. These data reveal that adenosine A1 receptors do not contribute to caffeine consumption, but determine the effects of caffeine on fluid intake and plasma renin concentration. |
