| First Author | Greig KT | Year | 2010 |
| Journal | Blood | Volume | 115 |
| Issue | 14 | Pages | 2796-805 |
| PubMed ID | 20130238 | Mgi Jnum | J:160794 |
| Mgi Id | MGI:4455111 | Doi | 10.1182/blood-2009-08-239210 |
| Citation | Greig KT, et al. (2010) Critical roles for c-Myb in lymphoid priming and early B-cell development. Blood 115(14):2796-805 |
| abstractText | c-Myb is a transcription factor with functions in many hematopoietic lineages. c-Myb-deficient mice display reduced numbers of B cells; however, it is unknown what role c-Myb plays in B lymphopoiesis because no critical target genes have been identified in the B-cell lineage. We demonstrate that conditional deletion of c-Myb in B-cell progenitors completely abolishes B-cell development. c-Myb is required for lymphoid progenitors to respond to the cytokines interleukin-7 and thymic stromal lymphopoietin; in the absence of sufficient c-Myb activity, mice display a B lymphopenia that closely resembles that observed in interleukin-7 receptor alpha-deficient animals. Analysis of the multipotent progenitor compartment indicates that c-Myb is also required for up-regulation of multiple lymphoid-associated genes, including Il7r, and for the subsequent development of the common lymphoid progenitor population. These data show that c-Myb plays a critical role in the regulatory pathways governing lymphoid specification and early B-cell differentiation. |
