| First Author | Yang T | Year | 2023 |
| Journal | Cell Rep | Volume | 42 |
| Issue | 10 | Pages | 113230 |
| PubMed ID | 37815917 | Mgi Jnum | J:348584 |
| Mgi Id | MGI:7542804 | Doi | 10.1016/j.celrep.2023.113230 |
| Citation | Yang T, et al. (2023) RORgammat(+) c-Maf(+) Vgamma4(+) gammadelta T cells are generated in the adult thymus but do not reach the periphery. Cell Rep 42(10):113230 |
| abstractText | T cell receptor (TCR) Vgamma4-expressing gammadelta T cells comprise interferon gamma (IFNgamma)- and interleukin-17 (IL-17)-producing effector subsets, with a preference for IL-17 effector fate decisions during early ontogeny. The existence of adult-thymus-derived IL-17(+) T cells (gammadelta17) remains controversial. Here, we use a mouse model in which T cells are generated exclusively in the adult thymus and employ single-cell chromatin state analysis to study their development. We identify adult-thymus-derived Vgamma4 T cells that have all the molecular programs to become IL-17 producers. However, they have reduced IL-17 production capabilities and rarely reach the periphery. Moreover, this study provides high-resolution profiles of Vgamma4 T cells in the adult thymus and lymph nodes and identifies Zeb1 as a potential gammadelta17 cell regulator. Together, this study provides valuable insights into the developmental traits of Vgamma4 T cells during adulthood and supports the idea of age-specific signals required for thymic export and/or peripheral maturation of gammadelta17 cells. |
