| Primary Identifier | MGI:2388558 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Hoxb7-RET/AKAP1)1Cos |
| Strain of Origin | (C57BL/6 x CBA)F2 | Is Recombinase | false |
| Is Wild Type | false |
| description | Trangenic founders all exhibit low transgene copy numbers and a low frequency of transmission to progeny. Four out of seven transgenic embryos examined at days E19-E19 displayed renal abnormalities. |
| molecularNote | The transgene consists of the tyrosine kinase domain of human RET fused to a portion of the human AKAP1 gene, followed by sequences from human beta globin. The fusion gene is found in certain papillary thyroid carcinomas as a result of chromosomal rearrangement. Mouse Hoxb7 promoter sequences drive transgene expression throughout the uretic bud branches. |
