| Primary Identifier | MGI:2388570 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(CD4-HIV)2Pjo |
| Strain of Origin | (C57BL/6 x C3H)F2 | Is Recombinase | false |
| Is Wild Type | false |
| description | Four transgenic founder lines were created and did not exhibit a phenotype. Transgenic animals remained healthy up to time of sacrifice, approximately 12 to 24 months. |
| molecularNote | The human CD4 promoter, 8.8 kb of HIV sequences, and an SV40 polyadenylation signal was used for the transgene. The promoter sequences were used to drive expression in CD4+ T cells and cells of the dendritic/macrophage lineage. Northern blot analysis showed barely detectable transgene expression in the thymus and spleen of transgenic animals. |
