| First Author | Mittrücker HW | Year | 1997 |
| Journal | Science | Volume | 275 |
| Issue | 5299 | Pages | 540-3 |
| PubMed ID | 8999800 | Mgi Jnum | J:42683 |
| Mgi Id | MGI:1096482 | Doi | 10.1126/science.275.5299.540 |
| Citation | Mittrucker HW, et al. (1997) Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science 275(5299):540-3 |
| abstractText | Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes. |
