| First Author | Sauter P | Year | 1997 |
| Journal | Immunobiology | Volume | 198 |
| Issue | 1-3 | Pages | 207-16 |
| PubMed ID | 9442392 | Mgi Jnum | J:45253 |
| Mgi Id | MGI:1194699 | Doi | 10.1016/S0171-2985(97)80041-1 |
| Citation | Sauter P, et al. (1997) The B cell-specific coactivator OBF-1 (OCA-B, Bob-1) is inducible in T cells and its expression is dispensable for IL-2 gene induction. Immunobiology 198(1-3):207-16 |
| abstractText | The transcriptional coactivator variously known as OBF-1, OCA-B or Bob-1 has previously been shown to be expressed in a highly B cell-specific manner. Here we show that expression of the OBF-1 gene is also observed in several T cell lines as well as in primary T cells following activation. This suggests that this coactivator may also be involved in transcriptional control in T lymphocytes. In addition we show that several potential T cell-specific target genes which have octamer sites in their regulatory regions, such as the genes coding for interleukin-2, -3 and -4, are still properly regulated in T cells isolated from OBF-1-/- mice. |
