| First Author | Jankovic M | Year | 2003 |
| Journal | Int Immunol | Volume | 15 |
| Issue | 9 | Pages | 1099-104 |
| PubMed ID | 12917262 | Mgi Jnum | J:85221 |
| Mgi Id | MGI:2673099 | Doi | 10.1093/intimm/dxg109 |
| Citation | Jankovic M, et al. (2003) OcaB regulates transitional B cell selection. Int Immunol 15(9):1099-104 |
| abstractText | OcaB, also known as Bob-1 or Obf-1, is a transcriptional co-activator which regulates Igkappa gene transcription, recombination and receptor editing; it is required for normal development of transitional B cells and for germinal center formation. Here we report that abnormal B cell development in OcaB(-/-) mice results in a skewed Igkappa repertoire including anti-DNA antibodies, suggesting that OcaB is essential for antibody repertoire selection. To determine whether OcaB is required for BCR-mediated B cell selection, we introduced a pre-recombined alpha hen egg lysozyme (HEL) Ig transgene into OcaB(-/-) mice. We find that in OcaB(-/-) mice expressing transgenic alphaHEL Ig bone marrow B cell development is normal up to the immature B cell stage, but fails to progress to the transitional B cell stage. We conclude that OcaB is required for normal selection of the antibody repertoire in developing B cells. |
