| Primary Identifier | MGI:2388119 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Mnat1 |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| description | Homozygous mutant embryos are inviable and die shortly after implantation. |
| molecularNote | An exon encoding 51 N-terminal amino acids comprising most of the RING finger domain was deleted and replaced with a PGK-neo cassette via homologous recombination. Western blot analysis of correctly targeted ES cells showed no detectable protein expression. Homozygous mutant embryos were observed at day E4.0 by PCR genotype analysis. |
