| First Author | Hu-Li J | Year | 2001 |
| Journal | Immunity | Volume | 14 |
| Issue | 1 | Pages | 1-11 |
| PubMed ID | 11163225 | Mgi Jnum | J:67964 |
| Mgi Id | MGI:1931792 | Doi | 10.1016/s1074-7613(01)00084-x |
| Citation | Hu-Li J, et al. (2001) Regulation of expression of IL-4 alleles: analysis using a chimeric GFP/IL-4 gene. Immunity 14(1):1-11 |
| abstractText | CD4 cells from mice heterozygous for an IL-4 and a GFP/IL-4 gene frequently express a single allele. Analysis of IL-4 or GFP production by cells from recently primed Th2 cells indicates that essentially all are competent to transcribe either allele but have a low probability of doing so. By contrast, long-term Th2 clones show distinct and heritable ratios in the proportion of cells that express IL-4 or GFP. We conclude that in the course of Th2 priming an early efficient event renders both alleles capable of being inefficiently transcribed; a second, less frequent event occurs that renders one allele more competent, accounting for the differential expression of IL-4 and GFP in different clones. |
