| First Author | Chen J | Year | 2013 |
| Journal | Nat Commun | Volume | 4 |
| Pages | 1955 | PubMed ID | 23736082 |
| Mgi Jnum | J:226224 | Mgi Id | MGI:5696504 |
| Doi | 10.1038/ncomms2955 | Citation | Chen J, et al. (2013) Hypothalamic proteoglycan syndecan-3 is a novel cocaine addiction resilience factor. Nat Commun 4:1955 |
| abstractText | Proteoglycans like syndecan-3 have complex signaling roles in addition to their function as structural components of the extracellular matrix. Here, we show that syndecan-3 in the lateral hypothalamus has an unexpected new role in limiting compulsive cocaine intake. In particular, we observe that syndecan-3 null mice self-administer greater amounts of cocaine than wild-type mice. This effect can be rescued by re-expression of syndecan-3 in the lateral hypothalamus with an adeno-associated viral vector. Adeno-associated viral vector delivery of syndecan-3 to the lateral hypothalamus also reduces motivation for cocaine in normal mice. Syndecan-3 limits cocaine intake by modulating the effects of glial-cell-line-derived neurotrophic factor, which uses syndecan-3 as an alternative receptor. Our findings indicate syndecan-3-dependent signaling as a novel therapeutic target for the treatment of cocaine addiction. |
