| First Author | Hienola A | Year | 2006 |
| Journal | J Cell Biol | Volume | 174 |
| Issue | 4 | Pages | 569-80 |
| PubMed ID | 16908672 | Mgi Jnum | J:112624 |
| Mgi Id | MGI:3662943 | Doi | 10.1083/jcb.200602043 |
| Citation | Hienola A, et al. (2006) N-syndecan deficiency impairs neural migration in brain. J Cell Biol 174(4):569-80 |
| abstractText | N-syndecan (syndecan-3) is a transmembrane proteoglycan that is abundantly expressed in the major axonal pathways and in the migratory routes of the developing brain. When ligated by heparin-binding (HB) growth-associated molecule (GAM; pleiotrophin), N-syndecan mediates cortactin-Src kinase-dependent neurite outgrowth. However, the functional role of N-syndecan in brain development remains unexplored. In this study, we show that N-syndecan deficiency perturbs the laminar structure of the cerebral cortex as a result of impaired radial migration. In addition, neural migration in the rostral migratory stream is impaired in the N-syndecan-null mice. We suggest that the migration defect depends on impaired HB-GAM-induced Src kinase activation and haptotactic migration. Furthermore, we show that N-syndecan interacts with EGF receptor (EGFR) at the plasma membrane and is required in EGFR-induced neuronal migration. |
