| First Author | Wang Y | Year | 2011 |
| Journal | Neurosci Lett | Volume | 502 |
| Issue | 1 | Pages | 30-2 |
| PubMed ID | 21798314 | Mgi Jnum | J:175768 |
| Mgi Id | MGI:5287302 | Doi | 10.1016/j.neulet.2011.07.018 |
| Citation | Wang Y, et al. (2011) Deletion of neuronal gap junction protein connexin 36 impairs hippocampal LTP. Neurosci Lett 502(1):30-2 |
| abstractText | In the mammalian CNS, deletion of neuronal gap junction protein, connexin 36 (Cx36), causes deficiencies in learning and memory. Here we tested whether Cx36 deletion affects the hippocampal long-term potentiation (LTP), which is considered as a cellular model of learning and memory mechanisms. We report that in acute slices of the hippocampal CA1 area, LTP is reduced in Cx36 knockout mice as compared to wild-type mice. Western blot analysis of NMDA receptor subunits indicates a higher NR2A/NR2B ratio in Cx36 knockout mice, indicating that there is shift in the threshold for LTP induction in knockout animals. Data suggest a possibility that learning and memory deficiencies in Cx36 knockout mice are due to deficiencies in LTP mechanisms. |
