| First Author | Deans MR | Year | 2002 |
| Journal | Neuron | Volume | 36 |
| Issue | 4 | Pages | 703-12 |
| PubMed ID | 12441058 | Mgi Jnum | J:107679 |
| Mgi Id | MGI:3621666 | Doi | 10.1016/s0896-6273(02)01046-2 |
| Citation | Deans MR, et al. (2002) Connexin36 is essential for transmission of rod-mediated visual signals in the mammalian retina. Neuron 36(4):703-12 |
| abstractText | To examine the functions of electrical synapses in the transmission of signals from rod photoreceptors to ganglion cells, we generated connexin36 knockout mice. Reporter expression indicated that connexin36 was present in multiple retinal neurons including rod photoreceptors, cone bipolar cells, and AII amacrine cells. Disruption of electrical synapses between adjacent AIIs and between AIIs and ON cone bipolars was demonstrated by intracellular injection of Neurobiotin. In addition, extracellular recording in the knockout revealed the complete elimination of rod-mediated, on-center responses at the ganglion cell level. These data represent direct proof that electrical synapses are critical for the propagation of rod signals across the mammalian retina, and they demonstrate the existence of multiple rod pathways, each of which is dependent on electrical synapses. |
