| First Author | Loh HH | Year | 1998 |
| Journal | Brain Res Mol Brain Res | Volume | 54 |
| Issue | 2 | Pages | 321-6 |
| PubMed ID | 9555078 | Mgi Jnum | J:47187 |
| Mgi Id | MGI:1202731 | Doi | 10.1016/s0169-328x(97)00353-7 |
| Citation | Loh HH, et al. (1998) mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality. Brain Res Mol Brain Res 54(2):321-6 |
| abstractText | The mu opioid receptor gene (MOR) was mutated in mice by a gene targeting procedure. In these MOR-knockout mice, the analgesic effects of morphine, its major metabolites, morphine-6-glucuronide (M-6-G) and morphine-6-ethereal sulfate (M-6-S), and endomorphin-2, as well as morphine-induced lethality, were drastically reduced, whereas the effects of DPDPE and U50488 remained unchanged. It is concluded that analgesic effects of mu-specific opioid ligands and acute morphine lethality are mediated by the mu receptor. Copyright 1998 Elsevier Science B.V. |
