| First Author | Jang CG | Year | 2001 |
| Journal | Brain Res Mol Brain Res | Volume | 94 |
| Issue | 1-2 | Pages | 197-9 |
| PubMed ID | 11597780 | Mgi Jnum | J:72339 |
| Mgi Id | MGI:2152485 | Doi | 10.1016/s0169-328x(01)00227-3 |
| Citation | Jang C, et al. (2001) Differential effects of morphine, DPDPE, and U-50488 on apomorphine-induced climbing behavior in ~mgr;-opioid receptor knockout mice. Brain Res Mol Brain Res 94(1-2):197-9 |
| abstractText | The present study examined the hypothesis whether the opioid receptors (&mgr;, delta, and kappa) contribute to a behavioral dopaminergic activation produced by dopamine receptor agonist, apomorphine, by comparing responses in wild type and &mgr;-opioid receptor knockout mice. The data suggest that expression of &mgr;-opioid receptors plays an important role in the enhancement of climbing behavior induced by apomorphine. Compared to wild type mice, a response in the dopaminergic behavior by treatment with delta-receptor agonist, DPDPE, is more sensitive to the mice lacking &mgr;-opioid receptor. Treatment with kappa-receptor agonist, U-50488, is potentiated the apomorphine-induced climbing behavior in wild type and &mgr;-opioid receptor knockout mice. These responses may be independent of that through &mgr;-opioid receptors. Therefore, the our results show that dopaminergic activation measured by climbing behavior in &mgr;-opioid receptors knockout mice are differently regulated by &mgr;-, delta-, and kappa-opioid receptor agonists. |
