| First Author | Roy S | Year | 1998 |
| Journal | Brain Res Mol Brain Res | Volume | 61 |
| Issue | 1-2 | Pages | 190-4 |
| PubMed ID | 9795212 | Mgi Jnum | J:56228 |
| Mgi Id | MGI:1340447 | Doi | 10.1016/s0169-328x(98)00212-5 |
| Citation | Roy S, et al. (1998) MU-opioid receptor-knockout mice: role of mu-opioid receptor in morphine mediated immune functions. Brain Res Mol Brain Res 61(1-2):190-4 |
| abstractText | The role of the mu-opioid receptor in immune function was investigated using mu-opioid receptor knockout mice (MOR-KO). Morphine modulation of several immune functions, including macrophage phagocytosis and macrophage secretion of TNF-alpha, was not observed in the MOR-KO animals, suggesting that these functions are mediated by the classical mu-opioid receptor. In contrast, morphine reduction of splenic and thymic cell number and mitogen-induced proliferation were unaffected in MOR-KO mice, as was morphine inhibition of IL-1 and IL-6 secretion by macrophages. These latter results are consistent with morphine action on a naloxone insensitive morphine receptor, a conclusion supported by previous studies characterizing a nonopioid morphine binding site on immune cells. Alternatively, morphine may act either directly or indirectly on these cells, by a mechanism mediated by either delta or kappa opioid receptors. Copyright 1998 Elsevier Science B.V. |
