| First Author | McCarthy LE | Year | 2004 |
| Journal | J Neuroimmunol | Volume | 153 |
| Issue | 1-2 | Pages | 91-8 |
| PubMed ID | 15265667 | Mgi Jnum | J:101856 |
| Mgi Id | MGI:3605582 | Doi | 10.1016/j.jneuroim.2004.04.006 |
| Citation | McCarthy LE, et al. (2004) The delta-opioid receptor participates in T-cell development by promoting negative selection. J Neuroimmunol 153(1-2):91-8 |
| abstractText | The delta-opioid receptor-1 (DOR-1) as well as delta-opioid enkephalin peptides are expressed during maturation of T cells, although the functional significance of their expression remains unclear. Based on results which show that the administration of the highly selective delta-opioid agonist D-Pen2, D-Pen5]enkephalin (DPDPE) induces an altered pattern of T-cell differentiation in fetal thymic organ culture (FTOC), we hypothesized that DOR-1 is involved in the negative selection process. Our results show that superantigen-induced clonal deletion is promoted by DPDPE and significantly impaired in DOR-1-deficient mice. These results suggest that delta-opioids may play a homeostatic role in the negative selection process during T-cell development. |
