| First Author | Dejima T | Year | 2011 |
| Journal | Infect Immun | Volume | 79 |
| Issue | 11 | Pages | 4503-10 |
| PubMed ID | 21875963 | Mgi Jnum | J:177775 |
| Mgi Id | MGI:5296265 | Doi | 10.1128/IAI.05799-11 |
| Citation | Dejima T, et al. (2011) Protective role of naturally occurring interleukin-17A-producing gammadelta T cells in the lung at the early stage of systemic candidiasis in mice. Infect Immun 79(11):4503-10 |
| abstractText | Interleukin-17A (IL-17A)-producing gammadelta T cells differentiate in the fetal thymus and reside in the peripheral tissues, such as the lungs of naive adult mice. We show here that naturally occurring gammadelta T cells play a protective role in the lung at a very early stage after systemic infection with Candida albicans. Selective depletion of neutrophils by in vivo administration of anti-Ly6G monoclonal antibody (MAb) impaired fungal clearance more prominently in the lung than in the kidney 24 h after intravenous infection with C. albicans. Rapid and transient production of IL-23 was detected in the lung at 12 h, preceding IL-17A production and the influx of neutrophils, which reached a peak at 24 h after infection. IL-17A knockout (KO) mice showed reduced infiltration of neutrophils concurrently with impaired fungal clearance in the lung after infection. The major source of IL-17A was the gammadelta T cell population in the lung, and Cdelta KO mice showed little IL-17A production and reduced neutrophil infiltration after infection. Early IL-23 production in a TLR2/MyD88-dependent manner and IL-23-triggered tyrosine kinase 2 (Tyk2) signaling were essential for IL-17A production by gammadelta T cells. Thus, our study demonstrated a novel role of naturally occurring IL-17A-producing gammadelta T cells in the first line of host defense against C. albicans infection. |
