| First Author | O'Connor W Jr | Year | 2009 |
| Journal | Nat Immunol | Volume | 10 |
| Issue | 6 | Pages | 603-9 |
| PubMed ID | 19448631 | Mgi Jnum | J:149452 |
| Mgi Id | MGI:3848558 | Doi | 10.1038/ni.1736 |
| Citation | O'Connor W Jr, et al. (2009) A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol 10(6):603-9 |
| abstractText | Interleukin 23 (IL-23) and IL-17 have been linked to the pathogenesis of several chronic inflammatory disorders, including inflammatory bowel disease. Yet as an important function for IL-23 is emerging, the function of IL-17 in inflammatory bowel disease remains unclear. Here we demonstrate IL-17A-mediated protection in the CD45RBhi transfer model of colitis. An accelerated wasting disease elicited by T cells deficient in IL-17A correlated with higher expression of genes encoding T helper type 1-type cytokines in colon tissue. IL-17A also modulated T helper type 1 polarization in vitro. Furthermore, T cells deficient in the IL-17 receptor elicited an accelerated, aggressive wasting disease relative to that elicited by wild-type T cells in recipient mice. Our data demonstrate a protective function for IL-17 and identify T cells as not only the source but also a target of IL-17 in vivo. |
