| First Author | Guidi CJ | Year | 2001 |
| Journal | Mol Cell Biol | Volume | 21 |
| Issue | 10 | Pages | 3598-603 |
| PubMed ID | 11313485 | Mgi Jnum | J:69009 |
| Mgi Id | MGI:1933896 | Doi | 10.1128/MCB.21.10.3598-3603.2001 |
| Citation | Guidi CJ, et al. (2001) Disruption of ini1 leads to peri-implantation lethality and tumorigenesis in mice. Mol Cell Biol 21(10):3598-603 |
| abstractText | SNF5/INI1 is a component of the ATP-dependent chromatin remodeling enzyme family SWI/SNF. Germ line mutations of INI1 have been identified in children with brain and renal rhabdoid tumors, indicating that INI1 is a tumor suppressor. Here we report that disruption of Ini1 expression in mice results in early embryonic lethality. Ini1-null embryos die between 3.5 and 5.5 days postcoitum, and Ini1-null blastocysts fail to hatch, form the trophectoderm, or expand the inner cell mass when cultured in vitro. Furthermore, we report that approximately 15% of Ini1-heterozygous mice present with tumors, mostly undifferentiated or poorly differentiated sarcomas. Tumor formation is associated with a loss of heterozygocity at the Ini1 locus, characterizing Ini1 as a tumor suppressor in mice. Thus, Ini1 is essential for embryo viability and for repression of oncogenesis in the adult organism. |
