| First Author | Newton PM | Year | 2004 |
| Journal | J Neurosci | Volume | 24 |
| Issue | 44 | Pages | 9862-9 |
| PubMed ID | 15525770 | Mgi Jnum | J:96593 |
| Mgi Id | MGI:3531001 | Doi | 10.1523/JNEUROSCI.3446-04.2004 |
| Citation | Newton PM, et al. (2004) Deletion of N-type calcium channels alters ethanol reward and reduces ethanol consumption in mice. J Neurosci 24(44):9862-9 |
| abstractText | N-type calcium channels are modulated by acute and chronic ethanol exposure in vitro at concentrations known to affect humans, but it is not known whether N-type channels are important for behavioral responses to ethanol in vivo. Here, we show that in mice lacking functional N-type calcium channels, voluntary ethanol consumption is reduced and place preference is developed only at a low dose of ethanol. The hypnotic effects of ethanol are also substantially diminished, whereas ethanol-induced ataxia is mildly increased. These results demonstrate that N-type calcium channels modulate acute responses to ethanol and are important mediators of ethanol reward and preference. |
