| Primary Identifier | MGI:2388483 | Allele Type | Targeted |
| Attribute String | Modified regulatory region, Null/knockout | Gene | Igh |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| description | The targeted IgH allele was of the a allotype. |
| molecularNote | Sequence encompassing a 3' Igh-D element (DQ52), the Igh-J elements, and the Igh intron enhancer (Rr150) was replaced with a cassette containing a neomycin resistance gene followed by sequence encoding the variable region of a phosphorylcholine antibody. Flow cytometry verified cell surface expression on peripheral blood lymphocytes obtained from heterozygous and homozygous mice. |
