| First Author | Moser EK | Year | 2019 |
| Journal | J Exp Med | Volume | 216 |
| Issue | 9 | Pages | 2170-2183 |
| PubMed ID | 31311822 | Mgi Jnum | J:280058 |
| Mgi Id | MGI:6364228 | Doi | 10.1084/jem.20181953 |
| Citation | Moser EK, et al. (2019) The E3 ubiquitin ligase Itch restricts antigen-driven B cell responses. J Exp Med 216(9):2170-2183 |
| abstractText | The E3 ubiquitin ligase Itch regulates antibody levels and prevents autoimmune disease in humans and mice, yet how Itch regulates B cell fate or function is unknown. We now show that Itch directly limits B cell activity. While Itch-deficient mice displayed normal numbers of preimmune B cell populations, they showed elevated numbers of antigen-experienced B cells. Mixed bone marrow chimeras revealed that Itch acts within B cells to limit naive and, to a greater extent, germinal center (GC) B cell numbers. B cells lacking Itch exhibited increased proliferation, glycolytic capacity, and mTORC1 activation. Moreover, stimulation of these cells in vivo by WT T cells resulted in elevated numbers of GC B cells, PCs, and serum IgG. These results support a novel role for Itch in limiting B cell metabolism and proliferation to suppress antigen-driven B cell responses. |
