| First Author | Pelanda R | Year | 1997 |
| Journal | Immunity | Volume | 7 |
| Issue | 6 | Pages | 765-75 |
| PubMed ID | 9430222 | Mgi Jnum | J:111431 |
| Mgi Id | MGI:3653984 | Doi | 10.1016/s1074-7613(00)80395-7 |
| Citation | Pelanda R, et al. (1997) Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification. Immunity 7(6):765-75 |
| abstractText | Mice carrying transgenic rearranged V region genes in their IgH and Igkappa loci to encode an autoreactive specificity direct the emerging autoreactive progenitors into a pre-B cell compartment, in which their receptors are edited by secondary Vkappa-Jkappa rearrangements and RS recombination. Editing is an efficient process, because the mutant mice generate normal numbers of B cells. In a similar nonautoreactive transgenic strain, neither a pre-B cell compartment nor receptor editing was seen. Thus, the pre-B cell compartment may have evolved to edit the receptors of autoreactive cells and later been generally exploited for efficient antibody diversification through the invention of the pre-B cell receptor, mimicking an autoreactive antibody to direct the bulk of the progenitors into that compartment. |
