| First Author | Alvarez-Zarate J | Year | 2015 |
| Journal | PLoS One | Volume | 10 |
| Issue | 6 | Pages | e0127178 |
| PubMed ID | 26057870 | Mgi Jnum | J:237705 |
| Mgi Id | MGI:5816652 | Doi | 10.1371/journal.pone.0127178 |
| Citation | Alvarez-Zarate J, et al. (2015) Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling. PLoS One 10(6):e0127178 |
| abstractText | Signaling through the inhibitory receptor signal regulatory protein-alpha (SIRPalpha) controls effector functions in phagocytes. However, there are also indications that interactions between SIRPalpha and its ligand CD47 are involved in phagocyte transendothelial migration. We have investigated the involvement of SIRPalpha signaling in phagocyte migration in vitro and in vivo using mice that lack the SIRPalpha cytoplasmic tail. During thioglycolate-induced peritonitis in SIRPalpha mutant mice, both neutrophil and macrophage influx were found to occur, but to be significantly delayed. SIRPalpha signaling appeared to be essential for an optimal transendothelial migration and chemotaxis, and for the amoeboid type of phagocyte migration in 3-dimensional environments. These findings demonstrate, for the first time, that SIRPalpha signaling can directly control phagocyte migration, and this may contribute to the impaired inflammatory phenotype that has been observed in the absence of SIRPalpha signaling. |
