| First Author | Bazzoli E | Year | 2012 |
| Journal | Cell Stem Cell | Volume | 11 |
| Issue | 6 | Pages | 836-44 |
| PubMed ID | 23217424 | Mgi Jnum | J:194667 |
| Mgi Id | MGI:5474498 | Doi | 10.1016/j.stem.2012.09.012 |
| Citation | Bazzoli E, et al. (2012) MEF promotes stemness in the pathogenesis of gliomas. Cell Stem Cell 11(6):836-44 |
| abstractText | High-grade gliomas are aggressive and uniformly fatal tumors, composed of a heterogeneous population of cells that include many with stem-cell-like properties. The acquisition of stem-like traits might contribute to glioma initiation, growth, and recurrence. Here we investigated the role of the transcription factor myeloid Elf-1 like factor (MEF, also known as ELF4) in gliomas. We found that MEF is highly expressed in both human and mouse glioblastomas and its absence impairs gliomagenesis in a PDGF-driven glioma mouse model. We show that modulation of MEF levels in both mouse neural stem cells and human glioblastoma cells has a significant impact on neurosphere formation. Moreover, we identify Sox2 as a direct downstream target of MEF. Taken together, our studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation. |
