| First Author | Yamada T | Year | 2010 |
| Journal | J Immunol | Volume | 185 |
| Issue | 7 | Pages | 3824-8 |
| PubMed ID | 20802152 | Mgi Jnum | J:164213 |
| Mgi Id | MGI:4830910 | Doi | 10.4049/jimmunol.1000718 |
| Citation | Yamada T, et al. (2010) Cutting edge: Expression of the transcription factor E74-like factor 4 is regulated by the mammalian target of rapamycin pathway in CD8+ T cells. J Immunol 185(7):3824-8 |
| abstractText | T cell receptor activation inhibits expression of the E74-like factor (ELF) 4 and Kruppel-like factor 4 genes to release naive CD8(+) T cells from their quiescent state. In this study, we show that ELF4 controls the ERK-mediated proliferative response by maintaining normal levels of dual-specificity phosphatases 1 and 5 in CD8(+) T cells. In activated CD8(+) T cells, the mammalian target of rapamycin pathway inhibits ELF4 and Kruppel-like factor 4 expression downstream of ERK and PI3K signaling. Our findings demonstrate that rapamycin could be used to modulate expression of this transcriptional network involved in cell-cycle regulation. |
