Primary Identifier | MGI:2389218 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(SFTPC-TGFA)1Kor |
Strain of Origin | FVB/N | Is Recombinase | false |
Is Wild Type | false |
description | This allele is representative of several transgenic founders (H8, H9, G2, E1, 43, and 44). Founders 43 and 44 are smaller compared to age-matched littermates. Founder H9 exhibits ruffled fur and appeared lethargic at time of death. |
molecularNote | The entire coding region of human TGFA was fused to the human SFTPC promoter and used for the transgene. Introns from the human growth factor gene were included to enhance transgene expression. The transgene is expressed in lung epithelial cells. |