| First Author | Lundholm M | Year | 2010 |
| Journal | J Immunol | Volume | 184 |
| Issue | 10 | Pages | 5537-44 |
| PubMed ID | 20400699 | Mgi Jnum | J:160996 |
| Mgi Id | MGI:4456919 | Doi | 10.4049/jimmunol.0904012 |
| Citation | Lundholm M, et al. (2010) Variation in the Cd3zeta (Cd247) gene correlates with altered T cell activation and is associated with autoimmune diabetes. J Immunol 184(10):5537-44 |
| abstractText | Tuning of TCR-mediated activation was demonstrated to be critical for lineage fate in T cell development, as well as in the control of autoimmunity. In this study, we identify a novel diabetes susceptibility gene, Idd28, in the NOD mouse and provide evidence that Cd3zeta (Cd247) constitutes a prime candidate gene for this locus. Moreover, we show that the allele of the Cd3zeta gene expressed in NOD and DBA/2 mouse strains confers lower levels of T cell activation compared with the allele expressed by C57BL/6 (B6), BALB/c, and C3H/HeJ mice. These results support a model in which the development of autoimmune diabetes is dependent on a TCR signal mediated by a less-efficient NOD allele of the Cd3zeta gene. |
