| First Author | Podolin PL | Year | 2000 |
| Journal | Cytokine | Volume | 12 |
| Issue | 5 | Pages | 477-82 |
| PubMed ID | 10857762 | Mgi Jnum | J:108210 |
| Mgi Id | MGI:3623429 | Doi | 10.1006/cyto.1999.0609 |
| Citation | Podolin PL, et al. (2000) Differential glycosylation of interleukin 2, the molecular basis for the NOD Idd3 type 1 diabetes gene?. Cytokine 12(5):477-82 |
| abstractText | The insulin-dependent diabetes (Idd) gene, Idd3, has been localised to a 0.35 cM region of chromosome 3 containing the structural gene for the cytokine interleukin 2 (IL-2). While variation of the N-terminal amino acid sequence of IL-2 has been shown to correlate with Idd3 allelic variation, differences in induction of proliferation by IL-2 allotypes have not been detected. In the current study, we examined the electrophoretic migration of IL-2 allotypes and have found two distinct patterns, consistent with differences in glycosylation, that correlate with diabetes-resistance and susceptibility. These findings strongly suggest that IL-2 variants may be functionally distinct. |
