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Allele : Tg(Myh6-ADRBK1)12Wjk transgene insertion 12, Walter Koch
Primary Identifier  MGI:2389028 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(Myh6-ADRBK1)12Wjk
Strain of Origin  (C57BL/6 x SJL)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  The entire bovine adrenergic receptor kinase, beta 1 (ADRBK1) coding region was ligated to a 5.5 kb fragment of the murine adult myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6) promoter. Overexpression of the transgenic protein was detected by Western blot analysis of heart extracts. Biochemical assays showed that kinase activity was approximately 3 times greater in heart extracts from transgenic mice than from wild-type mice. The Myh6 promoter drives expression in myocardial tissue.
  • mutations:
  • Insertion
  • synonyms:
  • Tg(BARK12)12Wjk,
  • TgGRK2,
  • Tg(BARK12)12Wjk,
  • TGBetaK12,
  • TGBetaK12,
  • TgGRK2,
  • BetaARK1 transgene,
  • BetaARK1 transgene
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1 Feature

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Genome

1 Expresses

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0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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1 Carried By

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1 Driven By

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9 Publication categories

Trail: Allele




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