| Primary Identifier | MGI:2389068 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Dpep1 |
| Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<b-m2> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The gene was disrupted by replacement of exon 1 and flanking sequences with a PGK-Hprt cassette via homologous recombination. The gene targeting event results in deletion of a splice acceptor site necessary for processing different protein isoforms, a 16 amino acid signal sequence, and 18 amino acids of the mature protein. Northern blot analysis of various tissues from homozygous mutant animals using a 620 bp cDNA probe did not detect gene expression. |
