| First Author | Rijkers ES | Year | 2008 |
| Journal | Mol Immunol | Volume | 45 |
| Issue | 4 | Pages | 1126-35 |
| PubMed ID | 17714785 | Mgi Jnum | J:126764 |
| Mgi Id | MGI:3761966 | Doi | 10.1016/j.molimm.2007.07.013 |
| Citation | Rijkers ES, et al. (2008) The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes. Mol Immunol 45(4):1126-35 |
| abstractText | To ensure an adequate response against pathogens and prevent unwanted self-reactivity, immune cells need to functionally express both activating and inhibitory receptors. CD200R is an inhibitory receptor mainly expressed on myeloid cells that down-modulates cellular activation both in vivo and in vitro. Although previously mainly studied as a regulator of myeloid function, we now show that CD200R is differentially expressed on human and mouse T-cell subsets. In both species, CD4(+) T cells express higher amounts of CD200R than CD8(+) T cells, and memory cells express higher amounts of CD200R than naive or effector cells. CD200R expression is up-regulated on both CD4(+) and CD8(+) T cells after stimulation in vitro. Furthermore, we show CD200R expression on human and mouse B cells. In human tonsils, CD200R is differentially expressed on B cells, with high expression on memory cells and plasmablasts. Mice lacking the ligand for CD200R, CD200(-/-) mice, do not show abnormal composition of the lymphocyte compartment and have normal B cell responses to antigenic challenge. Although the functional implications remain to be elucidated, the expression of CD200R on lymphocytes suggests a much broader role for CD200R-mediated immune regulation than previously anticipated. |
