| First Author | Kopsidas CA | Year | 2024 |
| Journal | iScience | Volume | 27 |
| Issue | 7 | Pages | 110199 |
| PubMed ID | 38989458 | Mgi Jnum | J:351471 |
| Mgi Id | MGI:7702967 | Doi | 10.1016/j.isci.2024.110199 |
| Citation | Kopsidas CA, et al. (2024) Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation. iScience 27(7):110199 |
| abstractText | Neurons in the neocortex are generated during embryonic development. While the adult ventricular-subventricular zone (V-SVZ) contains cells with neural stem/progenitors' characteristics, it remains unclear whether it has the capacity of producing neocortical neurons. Here, we show that generating neurons with transcriptomic resemblance to upper layer neocortical neurons continues in the V-SVZ of mouse models of a human condition known as periventricular heterotopia by abrogating Flna and Flnb. We found such surplus neurogenesis was associated with V-SVZ's upregulation of oxidative phosphorylation, mitochondrial biogenesis, and vascular abundance. Additionally, spatial transcriptomics analyses showed V-SVZ's neurogenic activation was coupled with transcriptional enrichment of genes in diverse pathways for energy metabolism, angiogenesis, cell signaling, synaptic transmission, and turnovers of nucleic acids and proteins in upper cortical layers. These findings support the potential of generating neocortical neurons in adulthood through boosting brain-wide vascular circulation, aerobic adenosine triphosphate synthesis, metabolic turnover, and neuronal activity. |
