Primary Identifier | MGI:2389262 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Camk2a |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exon 2 was flanked by loxP sites and excised in vitro by the transient expression of cre recombinase. The deletion of exon 2 results in a frameshift mutation affecting sequence downstream of exon 1. An absence of normal protein in homozygous mutant mice was confirmed by Western blot analysis. |