| First Author | Shimoda K | Year | 2002 |
| Journal | J Immunol | Volume | 169 |
| Issue | 9 | Pages | 4707-11 |
| PubMed ID | 12391177 | Mgi Jnum | J:79815 |
| Mgi Id | MGI:2388966 | Doi | 10.4049/jimmunol.169.9.4707 |
| Citation | Shimoda K, et al. (2002) Cutting edge: Tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-alpha-induced suppression of B lymphocyte formation. J Immunol 169(9):4707-11 |
| abstractText | IFN-alpha inhibits B lymphocyte development, and the nuclear protein Daxx has been reported to be essential for this biological activity. We show in this study that IFN-alpha inhibits the clonal proliferation of B lymphocyte progenitors in response to IL-7 in wild-type, but not in tyk2-deficient, mice. In addition, the IFN-alpha-induced up-regulation and nuclear translocation of Daxx are completely abrogated in the absence of tyk2. Therefore, tyk2 is directly involved in IFN-alpha signaling for the induction and translocation of Daxx, which may result in B lymphocyte growth arrest and/or apoptosis. |
