| First Author | Ishizaki M | Year | 2011 |
| Journal | Int Immunol | Volume | 23 |
| Issue | 9 | Pages | 575-82 |
| PubMed ID | 21765170 | Mgi Jnum | J:176033 |
| Mgi Id | MGI:5288157 | Doi | 10.1093/intimm/dxr057 |
| Citation | Ishizaki M, et al. (2011) Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice. Int Immunol 23(9):575-82 |
| abstractText | Tyrosine kinase-2 (Tyk2) participates in the signaling pathways of multiple cytokines in innate and acquired immunity. In the present study, we investigated the in vivo involvement of Tyk2 in anti-type II collagen antibody-induced arthritis (CAIA) using Tyk2-deficient mice. Hind paws of wild-type mice showed massive swelling and erythema by arthritogenic antibody injection, whereas Tyk2-deficient mice did not show any signs of arthritis. Indeed, neither the infiltration of inflammatory cells nor the fibrillation of articular cartilages was observed in Tyk2-deficient mice. Tyk2 deficiency also reduced the production of T(h)1/T(h)17-related cytokines, the other proinflammatory cytokines and matrix metalloproteases, which are induced in the CAIA paw. Our results demonstrate a critical contribution of Tyk2 in the development of arthritis, and we propose that Tyk2 might be an important candidate for drug development. |
