| First Author | Pelengaris S | Year | 1999 |
| Journal | Mol Cell | Volume | 3 |
| Issue | 5 | Pages | 565-77 |
| PubMed ID | 10360173 | Mgi Jnum | J:55801 |
| Mgi Id | MGI:1339420 | Doi | 10.1016/s1097-2765(00)80350-0 |
| Citation | Pelengaris S, et al. (1999) Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. Mol Cell 3(5):565-77 |
| abstractText | The protooncogene c-myc regulates cell growth, differentiation, and apoptosis, and its aberrant expression is frequently observed in human cancer. However, the consequences of activating c-Myc in an adult tissue, in which these cellular processes are part of normal homeostasis, remain unknown. In order to achieve this, we have targeted expression of a switchable form of the c-Myc protein to the skin epidermis, a well characterized homeostatic tissue. We show that activation of c-MycER in adult suprabasal epidermis rapidly triggers proliferation and disrupts differentiation of postmitotic keratinocytes. Sustained activation of c-Myc is sufficient to induce papillomatosis together with angiogenesis--changes that resemble hyperplastic actinic keratosis, a commonly observed human precancerous epithelial lesion. All these premalignant changes spontaneously regress upon deactivation of c-MycER. |
