| First Author | Kallies A | Year | 2009 |
| Journal | Immunity | Volume | 31 |
| Issue | 2 | Pages | 283-95 |
| PubMed ID | 19664942 | Mgi Jnum | J:151858 |
| Mgi Id | MGI:4355454 | Doi | 10.1016/j.immuni.2009.06.021 |
| Citation | Kallies A, et al. (2009) Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses. Immunity 31(2):283-95 |
| abstractText | In response to viral infection, naive CD8(+) T cells proliferate and differentiate into cytotoxic and cytokine-producing effector cells. Here we showed that the transcription factor Blimp-1, a crucial regulator of plasma cell differentiation, was required for CD8(+) T cells to differentiate into functional killer T cells in response to influenza virus. Blimp-1 was not essential for the generation of memory T cells but was crucial for their efficient recall response upon reinfection. Antigen-specific Blimp-1-deficient CD8(+) T cells failed to appropriately regulate the transcriptional program essential for killer T cell responses and showed impaired migration to the site of infection. This study identifies Blimp-1 as a master regulator of the terminal differentiation of CD8(+) effector T cells and uncovers a conservation of the pathways that regulate the terminal differentiation of T and B cells. |
