| First Author | O'Hare JK | Year | 2022 |
| Journal | Science | Volume | 375 |
| Issue | 6586 | Pages | eabm1670 |
| PubMed ID | 35298275 | Mgi Jnum | J:324881 |
| Mgi Id | MGI:7256785 | Doi | 10.1126/science.abm1670 |
| Citation | O'Hare JK, et al. (2022) Compartment-specific tuning of dendritic feature selectivity by intracellular Ca(2+) release. Science 375(6586):eabm1670 |
| abstractText | Dendritic calcium signaling is central to neural plasticity mechanisms that allow animals to adapt to the environment. Intracellular calcium release (ICR) from the endoplasmic reticulum has long been thought to shape these mechanisms. However, ICR has not been investigated in mammalian neurons in vivo. We combined electroporation of single CA1 pyramidal neurons, simultaneous imaging of dendritic and somatic activity during spatial navigation, optogenetic place field induction, and acute genetic augmentation of ICR cytosolic impact to reveal that ICR supports the establishment of dendritic feature selectivity and shapes integrative properties determining output-level receptive fields. This role for ICR was more prominent in apical than in basal dendrites. Thus, ICR cooperates with circuit-level architecture in vivo to promote the emergence of behaviorally relevant plasticity in a compartment-specific manner. |
