| First Author | Mo C | Year | 2013 |
| Journal | Behav Brain Res | Volume | 253 |
| Pages | 318-22 | PubMed ID | 23916759 |
| Mgi Jnum | J:202356 | Mgi Id | MGI:5518520 |
| Doi | 10.1016/j.bbr.2013.07.041 | Citation | Mo C, et al. (2013) Short-term memory acquisition in female Huntington's disease mice is vulnerable to acute stress. Behav Brain Res 253:318-22 |
| abstractText | Huntington's disease (HD) is a neurodegenerative disorder marked by cognitive, psychiatric and motor decline, and is modifiable by unidentified environmental factors. We examined the effects of stress on cognitive function in R6/1 HD transgenic mice. Utilizing the Y-maze to assess short-term memory, we report that only female HD mice displayed vulnerability to 1h of confinement stress reflected by impaired memory acquisition. This could not be attributed to a different corticosterone response or exploratory behaviour in the task. This is the first demonstration of increased stress susceptibility in an animal model of HD involving a direct negative impact on cognitive function. |
