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Allele : Ccnb2<tm1Thnt> cyclin B2; targeted mutation 1, Tim Hunt

Primary Identifier  MGI:2429974 Allele Type  Targeted
Attribute String  Null/knockout Gene  Ccnb2
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  Exons 4 and 5 were replaced with a neomycin selection cassette. The deleted sequence encoded the conserved cyclin box involved in the binding of cell cycle division 2. While neither mRNA nor protein was detected in homozygous mutant mice by Northern and Western blot analyses, 5' and amino terminal fragments were expected in vivo.
  • mutations:
  • Insertion,
  • Intragenic deletion
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

7 Publication categories

Trail: Allele