| Primary Identifier | MGI:2429773 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Null/knockout | Gene | Snca |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A floxed region containing neo and a transcriptional blocking sequence (STOP) was followed by human sequence encoding a modified SNCA gene. This construct was incorporated 7 bp upstream of the endogenous start codon via homologous recombination. Northern and Western blot analyses of homozygous mutant mice indicated a complete ablation of gene expression. The positioning of the human sequence downstream of the transcription blocking cassette precluded its expression. |
