| First Author | Matsuda J | Year | 1997 |
| Journal | Brain Dev | Volume | 19 |
| Issue | 1 | Pages | 19-20 |
| PubMed ID | 9071485 | Mgi Jnum | J:40522 |
| Mgi Id | MGI:700162 | Doi | 10.1016/s0387-7604(96)00077-0 |
| Citation | Matsuda J, et al. (1997) Neurological manifestations of knockout mice with beta-galactosidase deficiency. Brain Dev 19(1):19-20 |
| abstractText | We succeeded in producing the beta-galactosidase-deficient knockout mouse by gene targeting in embryonic stem cells. The mutant mice developed progressive spastic diplegia within a few months after birth, and died of emaciation at 7-10 months of age. This is an authentic murine model of human G(M1)-gangliosidosis, and is useful for studies of its pathogenesis and treatment. (C) 1997 Elsevier Science B.V. |
