| First Author | Hanahan D | Year | 1985 |
| Journal | Nature | Volume | 315 |
| Issue | 6015 | Pages | 115-22 |
| PubMed ID | 2986015 | Mgi Jnum | J:50695 |
| Mgi Id | MGI:1327868 | Doi | 10.1038/315115a0 |
| Citation | Hanahan D (1985) Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315(6015):115-22 |
| abstractText | Following the transfer into fertilized mouse eggs of recombinant genes composed of the upstream region of the rat insulin II gene linked to sequences coding for the large-T antigen of simian virus 40, large-T antigen is detected exclusively in the beta-cells of the endocrine pancreas of transgenic mice. The alpha- and delta-cells normally found in the islets of Langerhans are rare and disordered. Well-vascularized beta-cell tumours arise in mice harbouring and inheriting these hybrid oncogenes. |
