| First Author | Herzig M | Year | 1999 |
| Journal | Biol Chem | Volume | 380 |
| Issue | 2 | Pages | 203-11 |
| PubMed ID | 10195427 | Mgi Jnum | J:54150 |
| Mgi Id | MGI:1334148 | Doi | 10.1515/BC.1999.028 |
| Citation | Herzig M, et al. (1999) An unexpected role for p53 in augmenting SV40 large T antigen-mediated tumorigenesis. Biol Chem 380(2):203-11 |
| abstractText | Simian virus 40 large T antigen transforms cells by sequestration and inactivation of the tumor suppressor proteins p53, retinoblastoma gene product (pRb), and the pRb-related proteins p107 and p130. Thus, the absence of functional p53 is expected to promote T antigen-mediated tumorigenesis. However, in a transgenic mouse model of T antigen-mediated beta cell carcinogenesis (Rip1Tag2), tumor volumes are significantly diminished when these mice are intercrossed with p53-deficient mice. Whereas the incidence of beta tumor cell apoptosis is unaffected, their proliferation rate is reduced in p53-deficient beta cell tumors in vivo and in cell lines established from these tumors in vitro. Biochemical analyses reveal higher levels of T antigen in wild-type tumor cells as compared to p53-deficient tumor cells. The data indicate that p53 stabilizes SV40 large T antigen, thereby augmenting its oncogenic potential as manifested by increased proliferation rates in wild-type beta tumor cells as compared to p53-deficient beta tumor cells. |
