| First Author | Song S | Year | 2005 |
| Journal | Nat Cell Biol | Volume | 7 |
| Issue | 9 | Pages | 870-9 |
| PubMed ID | 16113679 | Mgi Jnum | J:102122 |
| Mgi Id | MGI:3606832 | Doi | 10.1038/ncb1288 |
| Citation | Song S, et al. (2005) PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol 7(9):870-9 |
| abstractText | The microvasculature consists of endothelial cells and their surrounding pericytes. Few studies on the regulatory mechanisms of tumour angiogenesis have focused on pericytes. Here we report the identification of tumour-derived PDGFRbeta (+) (platelet-derived growth factor receptor beta) progenitor perivascular cells (PPCs) that have the ability to differentiate into pericytes and regulate vessel stability and vascular survival in tumours. A subset of PDGFRbeta (+) PPCs is recruited from bone marrow to perivascular sites in tumours. Specific inhibition of PDGFRbeta signalling eliminates PDGFRbeta (+) PPCs and mature pericytes around tumour vessels, leading to vascular hyperdilation and endothelial cell apoptosis in pancreatic islet tumours of transgenic Rip1Tag2 mice. |
