| First Author | Christofori G | Year | 1995 |
| Journal | Nat Genet | Volume | 10 |
| Issue | 2 | Pages | 196-201 |
| PubMed ID | 7663515 | Mgi Jnum | J:24904 |
| Mgi Id | MGI:73441 | Doi | 10.1038/ng0695-196 |
| Citation | Christofori G, et al. (1995) Deregulation of both imprinted and expressed alleles of the insulin-like growth factor 2 gene during beta-cell tumorigenesis. Nat Genet 10(2):196-201 |
| abstractText | In a mouse model of multistage carcinogenesis elicited by the SV40 large T-antigen (Tag) oncogene in pancreatic beta cells, the gene for insulin-like growth factor IGF2 is focally up-regulated and functionally implicated in tumour development. The IGF2 gene is differentially regulated in normal tissues: the paternal allele is transiently expressed during embryogenesis, whereas the maternal allele is genomically imprinted and inactive. Crossbred mice carrying the Tag oncogene and a disruption of either the paternal or maternal allele of IGF2 reveal that both alleles are co-activated early during tumour development, and that each contributes to malignant hyperproliferation and consequent tumour volume. |
